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News After absorption in skin, pantothenyl alcohol is transformed into pantothenic acid (vitamin B5). Therefore, the effects of the pantothenic acid in skin can be induced by the application of pantothenyl alcohol. Pantothenic acid is an integral ingredient of the coenzyme A, a key molecule of the cellular metabolism. Owing to the consumption of coenzyme A being relatively high especially in skin, the pantothenic acid is considered to be essential for the normal function of the epidermis. In case of disturbances of the epidermis the requirement of this substance increases significantly. For a long time already there has been evidence based on in vitro analyses that pantothenyl alcohol exerts a positive influence on epithelial cells. Furthermore, according to a so-called classic study on dermatopharmacokinetics it is known that the active substance is in a position to penetrate the skin after topical application. In contrast, insights relating to the actual dermatological benefit of the substance could only be gained recently.: Korting cited in Zurich a study by Presto and colleagues, recently published in a magazine for dermatological diseases according to which for a hand care cream containing five percent pantothenyl alcohol a statistically significant acceleration of an epidermal regeneration has been found towards placebo as well as towards the control in an established wound-healing model. Major target parameter of this examination was the transepidermal waterloss (TEWL) which is increased at an impairment of the epidermal barrier in contrast to the normal condition.
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